Brain Enzyme a Factor in Weight Loss

More research on our rodent friends who by now should have every mechanism worked out in order that they stay slim.

Blocking a particlar enzyme (CaMKK2) was shown to decreases appetite And promote weight loss.

I found this observation odd:

They also studied both normal mice and mice missing CaMKK2 to learn how these types responded to low-fat and high-fat diets. After nearly 30 weeks on the specific diets, the normal mice on the high-fat diet became diabetic — they were unable to respond to insulin and weren’t able to manage blood sugar levels well. In contrast, the normal mice on a low-fat diet stayed healthy.

In mice missing CaMKK2, the scientists found that they stayed healthy regardless of whether they were on a low-fat or high-fat diet. The CAMKK2-negative mice apparently were protected from changes that lead to diabetes in a high-fat diet.

I don’t understand how a high-fat and presumeably low-carb thus low insulin producing diet would lead to diabetes. I’m open to suggestions. I assume we don’t have all the facts.

I suppose if the carb-content of the two diets remained the same it could make sense…?

Duke Medical News



Tidbits over the last month worth a mention…

Shake it Baby
In a bizarre experiment, mice were “vibrated” for 15 minutes a day resulting in fat loss and corresponding bone density increases. Can we vibrate those pounds away? Well we had one of those crazy machines in the basement for years and it did nothing for mother…

Vestigial What?
Just last month I had a doctor telling me I should “chop off my appendix” given my history of IBS and “it’s useless anyway.” I was sceptical that mother nature was that inefficient and opted to keep it to the rolling eyes of the specialist. Well ha, ha! HA! Appendix not useless afterall. Seems like it’s a little factory and warehouse of good bacteria. Pwned!

Type 3
Discovery supports theory of Alzheimer’s disease as a form of diabetes. All that sugar is going to your head. Levels of brain insulin and its related receptors are lower in individuals with Alzheimer’s disease.

Finish that Avocado
Monounsaturated Fat Improves Insulin Sensitivity. Eating a diet rich in monounsaturated fat reverses insulin resistance compared to diets rich in carbohydrates or saturated fat.

Big Where it Counts
Big hips mean big brains. Curvy women birthed children with superior cognitive abilities.

Quick-burning carbs may cause fatty liver

MiceCity Mouse and Country Mouse

Here’s an interesting one: two sets of mice were fed identical diets of corn starch with equal calories… but the corn starch had a high glycemic index (“GI”) for one group and a low GI for the other. The result: six months later the mice weighed the same!

BUT (the big but), their body compositions differed singificantly: the high GI group had twice the normal amount of fat in their bodies, blood and livers. The low GI diet mice had normal fat levels.

Besides being a good promo for a low GI diet, the results also show that measuring your health by the scales alone is a big mistake.

Full Article. Via Modern Forager.

Exercise Pill on the Way?

By giving ordinary adult mice a drug – a synthetic designed to mimic fat – Salk Institute scientist Dr. Ronald M. Evans is now able to chemically switch on PPAR-d, the master regulator that controls the ability of cells to burn fat. Even when the mice are not active, turning on the chemical switch activates the same fat-burning process that occurs during exercise. The resulting shift in energy balance (calories in, calories burned) makes the mice resistant to weight gain on a high fat diet.

The Salk Institute scientist who earlier discovered that enhancing the function of a single protein produced a mouse with an innate resistance to weight gain and the ability to run a mile without stopping, has found new evidence that this protein and a related protein play central roles in the body’s complex journey to obesity and offer a new and specific metabolic approach to the treatment of obesity related disease such as Syndrome X (insulin resistance, hyperlipidemia and atherosclerosis).

Via | Marathon Mouse Keeps on Running