More research on our rodent friends who by now should have every mechanism worked out in order that they stay slim.
Blocking a particlar enzyme (CaMKK2) was shown to decreases appetite And promote weight loss.
I found this observation odd:
They also studied both normal mice and mice missing CaMKK2 to learn how these types responded to low-fat and high-fat diets. After nearly 30 weeks on the specific diets, the normal mice on the high-fat diet became diabetic — they were unable to respond to insulin and weren’t able to manage blood sugar levels well. In contrast, the normal mice on a low-fat diet stayed healthy.
In mice missing CaMKK2, the scientists found that they stayed healthy regardless of whether they were on a low-fat or high-fat diet. The CAMKK2-negative mice apparently were protected from changes that lead to diabetes in a high-fat diet.
I don’t understand how a high-fat and presumeably low-carb thus low insulin producing diet would lead to diabetes. I’m open to suggestions. I assume we don’t have all the facts.
I suppose if the carb-content of the two diets remained the same it could make sense…?